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Type I/type III IFN and related factors regulate JEV infection and BBB endothelial integrity

27 Sept 2023

Abstract excerpt

BACKGROUND: Japanese encephalitis virus (JEV) remains a predominant cause of Japanese encephalitis (JE) globally. Its infection is usually accompanied by disrupted blood‒brain barrier (BBB) integrity and central nervous system (CNS) inflammation in a poorly understood pathogenesis. Productive JEV infection in brain microvascular endothelial cells (BMECs) is considered the initial event of the virus in penetrating...

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PMID: 37752509
DOI: 10.1186/s12974-023-02891-x

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