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Article

Deep spatial profiling of Venezuelan equine encephalitis virus reveals increased genetic diversity amidst neuroinflammation and cell death during brain infection.

Journal of virology - 31 Aug 2023

Williams Evan P, Xue Yi, Lee Jasper, Fitzpatrick Elizabeth A, Kong Ying, Reichard Walter, Writt Haley, Jonsson Colleen B

Abstract excerpt

Venezuelan equine encephalitis virus (VEEV) causes a febrile illness that can progress to neurological disease with the possibility of death in human cases. The evaluation and optimization of therapeutics that target brain infections demands knowledge of the host's response to VEEV, the dynamics of infection, and the potential for within-host evolution of the virus. We hypothesized that selective pressures during...

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Identifiers

PMID: 37560924
DOI: 10.1128/jvi.00827-23
PMCID: PMC10506382

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