Article

The selection arena in early human blastocysts resolves the pluripotent inner cell mass

2018-05-18

Abstract excerpt

Is the human early embryo unique in lacking an inner cell mass (ICM) and having parallel rather than step-wise development? Here we reanalyse single-cell transcriptomic data and stain human embryos in situ to reveal both classical step-wise development and the missing ICM, a transcriptomic homolog of macaque ICM, that differentiates to epiblast and primitive endoderm. This apparent classicism obscures numerous fea...

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Literature Corpus work: 79b641e1-9d21-592f-8954-3a1f1d853788
DOI: 10.1101/318329

Open publication

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