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Multi-Layered Molecular Profiling Informs the Diagnosis and Targeted Therapy of Desmoplastic Small Round Cell Tumor

2025-03-27

Abstract excerpt

<title>Abstract</title> <p> Desmoplastic small round cell tumor (DSRCT) is an ultra-rare sarcoma with limited treatment options. We performed whole-genome/exome, transcriptome, and DNA methylome analysis in 30 refractory DSRCT patients, complemented by (phospho)proteomic profiling in nine, within a nationwide precision oncology program. In eight patients (27%), DSRCT was diagnosed based on molecular profiling. A...

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Literature Corpus work: af101723-ef50-5f36-ba44-3365caf2ea47
DOI: 10.21203/rs.3.rs-6104125/v1

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