Article

Desmoplastic Small Round Cell Tumor: A Review of Main Molecular Abnormalities and Emerging Therapy

2020-12-11

Abstract excerpt

Desmoplastic small round cell tumor (DSRCT) is an extremely rare, aggressive sarcoma affecting adolescents and young adults with male predominance. Generally, it originates from serosal surface of abdominal cavity. The hallmark characteristic of DSRCT is the EWSR1-WT1 gene fusion. This translocation up-regulates the expression of PDGFRα, VEGF and other proteins related to tumor and vascular cell proliferatio...

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Literature Corpus work: 96fcdf7f-73d0-5539-a64e-c7edcb9a99f6
DOI: 10.20944/preprints202012.0288.v1

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