Article
Novel secondary somatic mutations in Ewing's sarcoma and desmoplastic small round cell tumors.
PloS one - 1 Jan 2014
Jiang Yunyun, Subbiah Vivek, Janku Filip, Ludwig Joseph A, Naing Aung, Benjamin Robert S, Brown Robert E, Anderson Pete, Kurzrock Razelle
Abstract excerpt
BACKGROUND: Ewing's sarcoma (ES) and desmoplastic small round cell tumors (DSRCT) are small round blue cell tumors driven by an N-terminal containing EWS translocation. Very few somatic mutations have been reported in ES, and none have been identified in DSRCT. The aim of this study is to explore potential actionable mutations in ES and DSRCT. METHODOLOGY: Twenty eight patients with ES or DSRCT had tumor tissue...
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