PML::RARA–negative APL-mimicking AML with a novel KMT2C–CREB3L2 fusion and RARA/RXRA-mediated sensitivity to all-trans retinoic acid

Abstract excerpt

<title>Abstract</title> <p>Classical acute promyelocytic leukemia (APL) is defined by the presence of the PML::RARA fusion; however, a subset of acute myeloid leukemia (AML) cases presents with morphological and clinical features highly suggestive of APL despite lacking this canonical rearrangement, creating diagnostic and therapeutic dilemmas. We report a 27-year-old woman initially diagnosed with AML characteri...

Topics

Open a Topic to create a Post that cites this publication.

• Acute Lymphoblastic Leukemia research
• Acute Myeloid Leukemia Research
• Advanced biosensing and bioanalysis techniques
• Antioxidant Activity and Oxidative Stress
• Histone Deacetylase Inhibitors Research
• Protein Degradation and Inhibitors
• Retinoids in leukemia and cellular processes

Identifiers and source

Literature Corpus work

aeeb7416-464b-5b5c-b0fa-eab675004049

DOI

10.21203/rs.3.rs-8640660/v1