Recurrent <i>RARB</i> Translocations in Acute Promyelocytic Leukemia Lacking <i>RARA</i> Translocation

Abstract excerpt

Abstract Translocations of retinoic acid receptor-α (RARA), typically PML–RARA, are a genetic hallmark of acute promyelocytic leukemia (APL). However, because a small fraction of APL lack translocations of RARA, we focused here on APL cases without RARA translocation to elucidate the molecular etiology of RARA-negative APL. We performed whole-genome sequencing, PCR, and FISH for five APL cases without RARA...

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