How retinoic acid and arsenic transformed acute promyelocytic leukemia therapy

doi:10.1530/jme-22-0141

Article

How retinoic acid and arsenic transformed acute promyelocytic leukemia therapy

16 Sept 2022

Abstract excerpt

Acute promyelocytic leukemia (APL) is associated with severe coagulopathy leading to rapid morbidity and mortality if left untreated. The definitive diagnosis of APL is made by identifying a balanced reciprocal translocation between chromosomes 15 and 17. This t(15;17) results in a fusion transcript of promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARA) genes and the expression of a functional...

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