Article
Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study.
Nutrients - 21 Nov 2021
Nounu Aayah, Richmond Rebecca C, Stewart Isobel D, Surendran Praveen, Wareham Nicholas J, Butterworth Adam, Weinstein Stephanie J, Albanes Demetrius, Baron John A, Hopper John L, Figueiredo Jane C, Newcomb Polly A, Lindor Noralane M, Casey Graham, Platz Elizabeth A, Marchand Loïc Le, Ulrich Cornelia M, Li Christopher I, van Dujinhoven Fränzel J B, Gsur Andrea, Campbell Peter T, Moreno Víctor, Vodicka Pavel, Vodickova Ludmila, Amitay Efrat, Alwers Elizabeth, Chang-Claude Jenny, Sakoda Lori C, Slattery Martha L, Schoen Robert E, Gunter Marc J, Castellví-Bel Sergi, Kim Hyeong-Rok, Kweon Sun-Seog, Chan Andrew T, Li Li, Zheng Wei, Bishop D Timothy, Buchanan Daniel D, Giles Graham G, Gruber Stephen B, Rennert Gad, Stadler Zsofia K, Harrison Tabitha A, Lin Yi, Keku Temitope O, Woods Michael O, Schafmayer Clemens, Van Guelpen Bethany, Gallinger Steven, Hampel Heather, Berndt Sonja I, Pharoah Paul D P, Lindblom Annika, Wolk Alicja, Wu Anna H, White Emily, Peters Ulrike, Drew David A, Scherer Dominique, Bermejo Justo Lorenzo, Brenner Hermann, Hoffmeister Michael, Williams Ann C, Relton Caroline L
Abstract excerpt
Salicylic acid (SA) has observationally been shown to decrease colorectal cancer (CRC) risk. Aspirin (acetylsalicylic acid, that rapidly deacetylates to SA) is an effective primary and secondary chemopreventive agent. Through a Mendelian randomization (MR) approach, we aimed to address whether levels of SA affected CRC risk, stratifying by aspirin use. A two-sample MR analysis was performed using GWAS summary...
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