Article
Intrinsic DNA topology as a prioritization metric in genomic fine-mapping studies
2019-11-11
Abstract excerpt
In genomic fine-mapping studies, some approaches leverage annotation data to prioritize likely functional polymorphisms. However, existing annotation sources often present challenges as many: lack data for novel variants, offer no context for noncoding regions, and/or are confounded with linkage disequilibrium. We propose a novel annotation source – sequence-dependent DNA topology – as a prioritization metric for...
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Identifiers and source
- Literature Corpus work
- aec33a0e-47ed-515b-b979-f5e4f5248a2a
- DOI
- 10.1101/837245