Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FineMAV: prioritizing candidate genetic variants driving local adaptations in human populations.

Genome biology - 17 Jan 2018

Szpak Michał, Mezzavilla Massimo, Ayub Qasim, Chen Yuan, Xue Yali, Tyler-Smith Chris

Abstract excerpt

We present a new method, Fine-Mapping of Adaptive Variation (FineMAV), which combines population differentiation, derived allele frequency, and molecular functionality to prioritize positively selected candidate variants for functional follow-up. We calibrate and test FineMAV using eight experimentally validated "gold standard" positively selected variants and simulations. FineMAV has good sensitivity and a low...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Biological
Share to Africa
Share to Asia, Eastern

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Computer Simulation

Share to Europe

Share to Selection, Genetic

Share to United States

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 29343290
DOI: 10.1186/s13059-017-1380-2
PMCID: PMC5771147

Genes

PRSS53
TGM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FineMAV: prioritizing candidate genetic variants driving local adaptations in human populations.PMID 29343290Read ↗

Stratifying variant deleteriousness and trait-modulating effect under human recent adaptationSemantic proximity Read ↗

Localizing recent adaptive evolution in the human genome.Semantic proximity Read ↗

Protein-coding repeat polymorphisms strongly shape diverse human phenotypes.Semantic proximity Read ↗

Identifying adaptive alleles in the human genome: from selection mapping to functional validation.Semantic proximity Read ↗

Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair.Semantic proximity Read ↗

Genome-wide detection and characterization of positive selection in human populations.Semantic proximity Read ↗

PopHumanVar: an interactive application for the functional characterization and prioritization of adaptive genomic variants in humans.Semantic proximity Read ↗

Genome-wide landscapes of human local adaptation in Asia.Semantic proximity Read ↗

Evolutionary history and adaptation from high-coverage whole-genome sequences of diverse African hunter-gatherers.Semantic proximity Read ↗

Tracing the evolution of human gene regulation and its association with shifts in environmentSemantic proximity Read ↗

Mosaic patterns of selection in genomic regions associated with diverse human traitsSemantic proximity Read ↗

Mosaic patterns of selection in genomic regions associated with diverse human traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.