Article
Local DNA topography correlates with functional noncoding regions of the human genome.
Science (New York, N.Y.) - 17 Apr 2009
Parker Stephen C J, Hansen Loren, Abaan Hatice Ozel, Tullius Thomas D, Margulies Elliott H
Abstract excerpt
The three-dimensional molecular structure of DNA, specifically the shape of the backbone and grooves of genomic DNA, can be dramatically affected by nucleotide changes, which can cause differences in protein-binding affinity and phenotype. We developed an algorithm to measure constraint on the basis of similarity of DNA topography among multiple species, using hydroxyl radical cleavage patterns to interrogate the...
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