Article
Prognostic value of chromosomal imbalances, gene mutations, and BAP1 expression in uveal melanoma.
Genes, chromosomes & cancer - 1 Aug 2018
Patrone Serena, Maric Irena, Rutigliani Mariangela, Lanza Francesco, Puntoni Matteo, Banelli Barbara, Rancati Silvia, Angelini Giovanna, Amaro Adriana, Ligorio Paolo, Defferrari Carlotta, Castagnetta Mauro, Bandelloni Roberto, Mosci Carlo, DeCensi Andrea, Romani Massimo, Pfeffer Urlich, Viaggi Silvia, Coviello Domenico A
Abstract excerpt
Uveal melanoma (UM) exhibits recurring chromosomal abnormalities and gene driver mutations, which are related to tumor evolution/progression. Almost half of the patients with UM develop distant metastases, predominantly to the liver, and so far there are no effective adjuvant therapies. An accurate UM genetic profile could assess the individual patient's metastatic risk, and provide the basis to determine an...
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