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Article

Metastatic ocular melanoma to the liver exhibits infiltrative and nodular growth patterns.

Human pathology - 1 Nov 2016

Grossniklaus Hans E, Zhang Qing, You Shuo, McCarthy Conni, Heegaard Steffen, Coupland Sarah E

Abstract excerpt

We examined liver specimens from 15 patients with uveal melanoma (UM) who had died of their disseminated disease. We found 2 distinct growth patterns of UM metastasis: infiltrative (n = 12) and nodular (n = 3). In the infiltrative pattern, individual UM cells with a CD133+ cancer stem cell-like phenotype were present and formed aggregates of stage I <50-μm-diameter micrometastases in the sinusoidal spaces. These...

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Source

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Identifiers

PMID: 27476775
DOI: 10.1016/j.humpath.2016.07.012
PMCID: PMC5547398

Genes

BAP1
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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