Article

Selection of rAAV Vectors that Cross the Human Blood-Brain Barrier and Target the Central Nervous System Using a Transwell Model

2022-07-06

Abstract excerpt

A limitation for rAAV-mediated gene transfer into the central nervous system (CNS) is the low penetration of vectors across the human blood-brain barrier (BBB). High doses of intravenously-delivered vector are required to reach the CNS, which has resulted in varying adverse effects. Moreover, selective transduction of various cell types might be important depending on the disorder being treated. To enhance BBB pen...

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Literature Corpus work: 01ce3fcf-a099-55de-afd9-33a4cadec7a8
DOI: 10.1101/2022.07.06.498990

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Selection of rAAV Vectors that Cross the Human Blood-Brain Barrier and Target the Central Nervous System Using a Transwell ModelDOI 10.1101/2022.07.06.498990Read

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