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Article

Role of Caveolin-1 in Inflammation: Genetic Predisposition and Potential Implication for Multiple Sclerosis.

Genes - 21 May 2026

Getachew Bruk, Miller Matthew R, Landis Harold E, Miller Robert E, Tizabi Yousef

Abstract excerpt

Multiple Sclerosis (MS) is a chronic, immune-mediated disorder of the central nervous system characterized by leukocyte infiltration, inflammation, demyelination, and progressive neurodegeneration. Susceptibility to MS is influenced by genetic factors, including variants within the human leukocyte antigen (HLA) region, (notably HLA-DR15), and multiple single nucleotide polymorphisms that modulate T cell function...

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Identifiers

PMID: 42195050
DOI: 10.3390/genes17050593
PMCID: PMC13206041

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