Article

GREB1 regulates proliferation of estrogen receptor positive breast cancer through modulation of PI3K/Akt/mTOR signaling

2019-07-16

Abstract excerpt

Over 70% of breast cancers express the estrogen receptor (ER) and depend on ER activity for survival and proliferation. While hormone therapies that target receptor activity are initially effective, patients invariably develop resistance which is often associated with activation of the PI3K/Akt/mTOR pathway. While the mechanism by which estrogen regulates proliferation is not fully understood, one gene target of E...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ae872780-ed04-59b4-a25b-99c14746cf0d
DOI: 10.1101/704825

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GREB1 regulates proliferation of estrogen receptor positive breast cancer through modulation of PI3K/Akt/mTOR signalingDOI 10.1101/704825Read

Nexus Between PI3K/AKT and Estrogen Receptor Signaling in Breast CancerSemantic proximity Read

BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast cancer.Semantic proximity Read

Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor–positive Breast CancerSemantic proximity Read

Targeting the PI3K/AKT/mTOR Pathway in Hormone-Positive Breast Cancer.Semantic proximity Read

GREB1 is an estrogen receptor-regulated tumour promoter that is frequently expressed in ovarian cancerSemantic proximity Read

An E2F1-dependent gene expression program that determines the balance between proliferation and cell death.Semantic proximity Read

The phosphoinositide-3-kinase-Akt-mTOR pathway as a therapeutic target in breast cancer.Semantic proximity Read

Sustained mTORC1 activity during palbociclib-induced growth arrest triggers senescence in ER+ breast cancer cellsSemantic proximity Read

Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR.Semantic proximity Read

P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.Semantic proximity Read

Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualizationSemantic proximity Read

Molecular mechanisms of estrogen receptor β -induced apoptosis and autophagy in tumors: implication for treating osteosarcomaSemantic proximity Read