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Article

P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer.

Oncogene - 23 Jul 2015

Dillon L M, Bean J R, Yang W, Shee K, Symonds L K, Balko J M, McDonald W H, Liu S, Gonzalez-Angulo A M, Mills G B, Arteaga C L, Miller T W

Abstract excerpt

Phosphatidylinositol 3-kinase (PI3K) promotes cancer cell survival, migration, growth and proliferation by generating phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the inner leaflet of the plasma membrane. PIP3 recruits pleckstrin homology domain-containing proteins to the membrane to activa...

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Source

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Identifiers

PMID: 25284585
DOI: 10.1038/onc.2014.328
PMCID: PMC4387124

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25284585-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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