Article
An E2F1-dependent gene expression program that determines the balance between proliferation and cell death.
Cancer cell - 1 Jan 2008
Hallstrom Timothy C, Mori Seiichi, Nevins Joseph R
Abstract excerpt
The Rb/E2F pathway regulates the expression of genes essential for cell proliferation but that also trigger apoptosis. During normal proliferation, PI3K/Akt signaling blocks E2F1-induced apoptosis, thus serving to balance proliferation and death. We now identify a subset of E2F1 target genes that are specifically repressed by PI3K/Akt signaling, thus distinguishing the E2F1 proliferative or apoptotic function....
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