Article

A Glycan-Based Ligand Panel for Phenotypic Profiling and Selective Immunomodulation of Alveolar Macrophage

2025-11-26

Abstract excerpt

The balance of alveolar macrophage (AM) polarization is severely disrupted in chronic in-flammatory diseases like bronchiectasis, where a persistent pro-inflammatory (M1) phe-notype perpetuates inflammation. To address this, we developed a high-throughput plat-form using a series of synthetic glycoligands (L1-L5) on a polyethyleneimine (PEI) scaf-fold. These ligands, which have varying affinities for macrophage le...

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Literature Corpus work: ae81d157-71e9-57cd-a114-26bf11b30fcb
DOI: 10.20944/preprints202511.1914.v1

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