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Article

The immunopathogenesis of rheumatoid arthritis.

Annual review of pathology - 1 Jan 2009

Imboden John B

Abstract excerpt

Rheumatoid arthritis is a chronic inflammatory polyarthritis whose etiology remains uncertain. Recently we have learned that autoimmunity to citrullinated protein antigens has specificity for rheumatoid arthritis and defines a clinically and genetically distinct form of the disease. Multiple genes contribute to disease susceptibility, with the HLA locus accounting for 30% to 50% of overall genetic risk. Five risk...

Read the complete abstract on PubMed

Topics

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Share to Arthritis, Experimental
Share to Arthritis, Rheumatoid
Share to Autoantibodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Disease Progression

Share to Peptides, Cyclic

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Share to T-Lymphocytes

Source

Identifiers

PMID: 18954286
DOI: 10.1146/annurev.pathol.4.110807.092254

Genes

PTPN22
STAT4
TRAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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