Back to search

Article

Targeted epigenetic repression of oncogenic transcription factors via CRISPR/dCas9 locus-specific silencing

2026-06-27

Abstract excerpt

Despite the revolutionary impact of genome engineering tools in medicine, the safe and effective intracellular delivery of CRISPR remains a major obstacle for clinical applications. Here, we implement precision molecular medicine and delivery strategies based on CRISPR/dCas9 systems adapted for epigenetic repression (dCas9-KRAB) to silence oncogenic drivers with high genomic selectivity. As proof-of-principle, we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ae597921-8365-59aa-baf1-da1919086ff2
DOI
10.64898/2026.06.27.734664
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Targeted epigenetic repression of oncogenic transcription factors via CRISPR/dCas9 locus-specific silencingDOI 10.64898/2026.06.27.734664
Development and potential applications of CRISPR-Cas9 genome editing technology in sarcoma.Semantic proximity
Harnessing Gene Editing Technology for Tumor Microenvironment Modulation: An Emerging Anticancer StrategySemantic proximity
AsCas12a ultra nuclease facilitates the rapid generation of therapeutic cell medicinesSemantic proximity
Advances in Cancer Treatment through Nanotheranostics and Emerging TherapiesSemantic proximity
Single-base precision design of CRISPR-Cas13b enables systematic silencing of oncogenic fusionsSemantic proximity
Single-base precision design of CRISPR-Cas13b enables systematic silencing of oncogenic fusionsSemantic proximity
Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteinsSemantic proximity
Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteinsSemantic proximity
Ultrasound Control of Genomic Regulatory Toolboxes for Cancer ImmunotherapySemantic proximity
From Editing Genes to Orchestrating Networks: CRISPR and the Future of Precision OncologySemantic proximity
From Editing Genes to Orchestrating Networks: CRISPR and the Future of Precision OncologySemantic proximity
Rational design of a compact CRISPR-Cas9 activator for AAV-mediated deliverySemantic proximity
Select a neighboring publication to make it the new centre.