Article

Multi-omics Differential Inference for Functional Interpretation (MoDIFI): A Statistical Framework to Prioritize Cell Lines for Neurodevelopmental Variants

2026-01-29

Abstract excerpt

Noncoding variants contribute to neurodevelopmental disorders (NDDs), but their regulatory effects are often cell-type specific, making it difficult to choose an in vitro model for high-throughput assays such as massively parallel reporter assays. We asked: given a set of noncoding variants, which cell line and regulatory regions are most likely to reveal measurable allele-specific effects? We generated matched mu...

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Literature Corpus work: ae3fa2f6-0761-5fee-bda2-c1f5be8e434d
DOI: 10.64898/2026.01.29.702065

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