Article

Deep learning-driven neuromorphogenesis screenings identify repurposable drugs for mitochondrial disease

2024-07-12

Abstract excerpt

<h4>Summary</h4> Mitochondrial disease encompasses untreatable conditions affecting tissues with high energy demands. A severe manifestation of mitochondrial disease is Leigh syndrome (Leigh), which causes defects in basal ganglia and midbrain regions, psychomotor regression, lactic acidosis, and early death. We previously generated isogenic pairs of Leigh cerebral organoids and uncovered defects in neuromorphoge...

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Literature Corpus work: ae388457-5503-514b-a5de-d1bcc1305296
DOI: 10.1101/2024.07.08.602501

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