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Article

Phenotypic approaches for CNS drugs.

Trends in pharmacological sciences - 1 Nov 2024

Sharma Raahul, Oyagawa Caitlin R M, Abbasi Hamid, Dragunow Michael, Conole Daniel

Abstract excerpt

Central nervous system (CNS) drug development is plagued by high clinical failure rate. Phenotypic assays promote clinical translation of drugs by reducing complex brain diseases to measurable, clinically valid phenotypes. We critique recent platforms integrating patient-derived brain cells, which most accurately recapitulate CNS disease phenotypes, with higher throughput models, including immortalized cells, to...

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PMID: 39438155
DOI: 10.1016/j.tips.2024.09.003

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