Article

Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through K <sub>v</sub> 7.4 channel upsurge in auditory neurons and hair cells

2022-03-04

Abstract excerpt

Repressor element 1-silencing transcription factor (REST) is a transcriptional repressor that recognizes neuron-restrictive silencer elements in the mammalian genomes in a tissue- and cell-specific manner. The identity of REST target genes and molecular details of how REST regulates them are emerging. We performed conditional null deletion of Rest (cKO) in murine hair cells (HCs) and auditory neurons, spiral gang...

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Literature Corpus work: ae1fea9a-d520-5970-a3ba-23769a35b8ad
DOI: 10.1101/2022.03.03.482811

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