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Article

Inhibition of a transcriptional repressor rescues hearing in a splicing factor-deficient mouse.

Life science alliance - 1 Dec 2020

Nakano Yoko, Wiechert Susan, Fritzsch Bernd, Bánfi Botond

Abstract excerpt

In mechanosensory hair cells (HCs) of the ear, the transcriptional repressor REST is continuously inactivated by alternative splicing of its pre-mRNA. This mechanism of REST inactivation is crucial for hearing in humans and mice. Rest is one of many pre-mRNAs whose alternative splicing is regulated by the splicing factor SRRM4; Srrm4 loss-of-function mutation in mice (Srrm4 bv/bv ) causes deafness, balance...

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Share to Alternative Splicing
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Share to Hearing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mechanotransduction, Cellular

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Source

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Identifiers

PMID: 33087486
DOI: 10.26508/lsa.202000841
PMCID: PMC7652395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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