Article

Sex-biased <i>ZRSR2</i> mutations in myeloid malignancies impair plasmacytoid dendritic cell activation and apoptosis

2020-10-29

Abstract excerpt

<h4>ABSTRACT</h4> Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive leukemia of plasmacytoid dendritic cells (pDCs). BPDCN occurs at least three times more frequently in men than women, but the reasons for this sex bias are unknown. Here, studying genomics of primary BPDCN and modeling disease-associated mutations, we link acquired alterations in RNA splicing to abnormal pDC development and in...

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Literature Corpus work: ae1d4b05-2004-59c7-8a3d-5f41549d8828
DOI: 10.1101/2020.10.29.360503

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