Article
Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis.
Cancer discovery - 1 Feb 2022
Togami Katsuhiro, Chung Sun Sook, Madan Vikas, Booth Christopher A G, Kenyon Christopher M, Cabal-Hierro Lucia, Taylor Justin, Kim Sunhee S, Griffin Gabriel K, Ghandi Mahmoud, Li Jia, Li Yvonne Y, Angelot-Delettre Fanny, Biichle Sabeha, Seiler Michael, Buonamici Silvia, Lovitch Scott B, Louissaint Abner, Morgan Elizabeth A, Jardin Fabrice, Piccaluga Pier Paolo, Weinstock David M, Hammerman Peter S, Yang Henry, Konopleva Marina, Pemmaraju Naveen, Garnache-Ottou Francine, Abdel-Wahab Omar, Koeffler H Phillip, Lane Andrew A
Abstract excerpt
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive leukemia of plasmacytoid dendritic cells (pDC). BPDCN occurs at least three times more frequently in men than in women, but the reasons for this sex bias are unknown. Here, studying genomics of primary BPDCN and modeling disease-associated mutations, we link acquired alterations in RNA splicing to abnormal pDC development and inflammatory...
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