The Clinicopathologic and Genomic Features of Mature Versus Blastic Plasmacytoid Dendritic Cell Neoplasms Arising From Chronic Myeloid Neoplasms.

doi:10.1097/PAS.0000000000002556

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The Clinicopathologic and Genomic Features of Mature Versus Blastic Plasmacytoid Dendritic Cell Neoplasms Arising From Chronic Myeloid Neoplasms.

The American journal of surgical pathology - 1 Aug 2026

Wu Sarah J, Hergott Christopher B, Griffin Gabriel K, Lane Andrew A, Luskin Marlise R, Larocca Cecilia A, LeBoeuf Nicole R, Matsumoto Nana P, Shimony Shai, Waller Brianna F, Wong Waihay J, Hasserjian Robert P, Kim Annette S, Morgan Elizabeth A, Sadigh Sam

Abstract excerpt

Clonal mature plasmacytoid dendritic cell proliferations (MPDCP) are a recently recognized entity in the WHO fifth edition, but their pathologic spectrum remains poorly characterized. Cases with extensive MPDCP in the bone marrow (BM) are rare and can exhibit overlapping features with blastic plasmacytoid dendritic cell neoplasm (BPDCN). We compared clinicopathologic and genomic features of 11 patients with...

Topics

Humans
Blastic Plasmacytoid Dendritic Cell Neoplasm
Female
Male
Aged
Biomarkers, Tumor
Middle Aged
Immunohistochemistry
Adult

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Dendritic Cells

Mutation

Aged, 80 and over

Genetic Predisposition to Disease

DNA Mutational Analysis

Phenotype

Source

Open in PubMed

Identifiers

PMID: 42008303
DOI: 10.1097/PAS.0000000000002556

Genes

SOX4
ASXL1
CD4
CD5
CD7
RUNX1
SRSF2
TCF4
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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