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Genome-wide DNA methylation-analysis of blastic plasmacytoid dendritic cell neoplasm identifies distinct molecular features.

Leukemia - 1 May 2024

Künstner Axel, Schwarting Julian, Witte Hanno M, Xing Pengwei, Bernard Veronica, Stölting Stephanie, Lohneis Philipp, Janke Florian, Salehi Maede, Chen Xingqi, Kusch Kathrin, Sültmann Holger, Chteinberg Emil, Fischer Anja, Siebert Reiner, von Bubnoff Nikolas, Merz Hartmut, Busch Hauke, Feller Alfred C, Gebauer Niklas

Abstract excerpt

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) constitutes a rare and aggressive malignancy originating from plasmacytoid dendritic cells (pDCs) with a primarily cutaneous tropism followed by dissemination to the bone marrow and other organs. We conducted a genome-wide analysis of the tumor methylome in an extended cohort of 45 BPDCN patients supplemented by WES and RNA-seq as well as ATAC-seq on selected...

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Identifiers

PMID: 38600314
DOI: 10.1038/s41375-024-02240-8
PMCID: PMC11073989

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