Article
Features of non-activation dendritic state and immune deficiency in blastic plasmacytoid dendritic cell neoplasm (BPDCN).
Blood cancer journal - 6 Dec 2019
Beird Hannah C, Khan Maliha, Wang Feng, Alfayez Mansour, Cai Tianyu, Zhao Li, Khoury Joseph, Futreal P Andrew, Konopleva Marina, Pemmaraju Naveen
Abstract excerpt
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, male-predominant hematologic malignancy with poor outcomes and with just one recently approved agent (tagraxofusp). It is characterized by the abnormal proliferation of precursor plasmacytoid dendritic cells (pDCs) with morphologic and molecular similarities to acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)/chronic myelomonocytic...
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