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Multiple receptor tyrosine kinases promote the in vitro phenotype of metastatic human osteosarcoma cell lines

19 Nov 2012

Abstract excerpt

The survival rate for osteosarcoma patients with localized disease is 70% and only 25% for patients with metastases. Therefore, novel therapeutic and prognostic tools are needed. In this study, extensive screening and validation strategies identified Axl, EphB2, FGFR2, IGF-1R and Ret as specific receptor tyrosine kinases (RTKs) that are activated and promote the in vitro phenotype of two genetically different...

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PMID: 23552467
DOI: 10.1038/oncsis.2012.34

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