Article

Modular Splicing is Linked to Evolution in the Synapse-Specificity Molecule Kirrel3

2023-07-28

Abstract excerpt

<h4>ABSTRACT</h4> Kirrel3 is a cell-adhesion molecule that instructs the formation of specific synapses during brain development in mouse and Kirrel3 variants may be risk factors for autism and intellectual disabilities in humans. Kirrel3 is predicted to undergo alternative splicing but brain isoforms have not been studied. Here, we present the first in-depth characterization of Kirrel3 isoform diversity in brain...

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Literature Corpus work: ae0bf442-9620-5a2b-8cb0-c727dd36396b
DOI: 10.1101/2023.07.25.550563

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