Article

Expression of the human immunomodulatory protein, human B7-1 (CD80), accelerates neuroinflammation, synaptic loss, microvascular instability and lethality in a murine model of Alzheimer’s Disease

2025-12-31

Abstract excerpt

Immune-mediated inflammatory processes play a pivotal role in the pathogenesis of Alzheimer’s disease (AD). However, immune loci exhibit significant sequence diversity, with human proteins sharing only ∼45–70% identity with their murine orthologs. This divergence contributes to the inability of many established mouse models to accurately capture key neuroinflammatory mechanisms relevant to human AD. We recently id...

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Literature Corpus work: ae0a89b0-2f30-5cef-8638-f23372b1cb14
DOI: 10.64898/2025.12.30.697078

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