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The monothiol glutaredoxin Grx4 interacts with the Cryptococcus iron regulator Cirl and regulates iron homeostasis and virulence in the <i>Cryptococcus neoformans</i>

2018-06-28

Abstract excerpt

The acquisition of iron and the maintenance of iron homeostasis are important aspects of the virulence in the pathogenic fungus Cryptococcus neoformans. In this study, we identified the monothiol glutaredoxin Grx4 as a binding partner of Cir1, a master regulator of iron-responsive genes and virulence factor elaboration in C. neoformans. Monothiol glutaredoxins are important regulators of iron homeostasis because...

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Literature Corpus work
fd75337b-3bff-50d7-9782-7571e5b03382
DOI
10.1101/356774
Open publication

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