Article
The Novel J-Domain Protein Mrj1 Is Required for Mitochondrial Respiration and Virulence in Cryptococcus neoformans.
mBio - 9 Jun 2020
Horianopoulos Linda C, Hu Guanggan, Caza Mélissa, Schmitt Kerstin, Overby Peter, Johnson James D, Valerius Oliver, Braus Gerhard H, Kronstad James W
Abstract excerpt
The opportunistic fungal pathogen Cryptococcus neoformans must adapt to the mammalian environment to establish an infection. Proteins facilitating adaptation to novel environments, such as chaperones, may be required for virulence. In this study, we identified a novel mitochondrial co-chaperone, Mrj1 (mitochondrial respiration J-domain protein 1), necessary for virulence in C. neoformans The mrj1Δ and...
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