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Article

Molecular architecture and diversity of StopGo/2A translational recoding

2025-11-07

Abstract excerpt

Viral 2A sequences trigger a co-translational peptide bond formation “skipping” event, termed “StopGo”, to generate two separate proteins from a single open reading frame without classical termination. To investigate the mechanism of StopGo, we determined the cryo-EM structure of a mammalian ribosome positioned at the foot-and-mouth disease virus 2A (F2A) site. The structure shows how interactions between the F2A...

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Literature Corpus work
adbd4fe7-b4e4-553e-b03e-be0eb7677e7c
DOI
10.1101/2025.11.07.687186
Open publication

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Molecular architecture and diversity of StopGo/2A translational recodingDOI 10.1101/2025.11.07.687186
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