Article

Deficiency of macrophage-derived Dnase1L3 causes lupus-like phenotypes in mice

2023-04-19

Abstract excerpt

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease caused by environmental factors and loss of key proteins. One such protein is a serum endonuclease secreted by macrophages and dendritic cells, Dnase1L3. Loss of Dnase1L3 causes pediatric-onset lupus in humans is Dnase1L3. Reduction in Dnase1L3 activity occurs in adult-onset human SLE. However, the amount of Dnase1L3 necessary to prevent lupus onse...

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Literature Corpus work: ada9eab1-b9f2-59e3-89f6-c09af67f499d
DOI: 10.1101/2023.04.17.537232

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