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Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA

28 Dec 2018

Abstract excerpt

Circulating DNA in plasma consists of short DNA fragments. The biological processes generating such fragments are not well understood. DNASE1L3 is a secreted DNASE1-like nuclease capable of digesting DNA in chromatin, and its absence causes anti-DNA responses and autoimmunity in humans and mice. We found that the deletion of Dnase1l3 in mice resulted in aberrations in the fragmentation of plasma DNA. Such...

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PMID: 30593563
DOI: 10.1073/pnas.1815031116

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