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Contribution of impaired DNASE1L3 activity to anti-DNA autoantibody production in systemic lupus erythematosus

1 Mar 2022

Abstract excerpt

Abstract Anti-DNA autoantibodies are pathogenic in systemic lupus erythematosus (SLE). Cell-free chromatin associated long DNA fragments are antigens for anti-DNA antibodies. In health state, released by cell death and actively secreted by live cells, these cell-free DNA are cleared by deoxyribonucleases (DNASES). In SLE, cell-free DNA are accumulated. The defective clearance of long fragments of cell-free DNA in...

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PMID: 36467024
DOI: 10.2478/rir-2022-0003

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