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Article

A deep dive into monogenic lupus: insights on DNASE1L3 mutation.

Rheumatology (Oxford, England) - 1 Jul 2025

Abdwani Reem, Mal Mahadev Jetho, Al Masroori Eman, Jaju Sanjay, Al Abrawi Safiya

Abstract excerpt

OBJECTIVE: In this study, we aim to describe the largest cohort of monogenic lupus caused by DNASE1L3 yet reported, describing its phenotypic characteristics and outcomes. METHODS: We performed a multicentre retrospective chart review for enrolled patients with childhood-onset SLE (cSLE) followed in paediatric rheumatology tertiary centers in the Sultanate of Oman. We included cSLE patients with genetically...

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Adolescent
Age of Onset
Child
Child, Preschool
Endodeoxyribonucleases
Lupus Erythematosus, Systemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39666950
DOI: 10.1093/rheumatology/keae679

Genes

DNASE1L3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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