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Article

Systems Biology Analysis Reveals Eight SLC22 Transporter Subgroups, Including OATs, OCTs, and OCTNs.

International journal of molecular sciences - 5 Mar 2020

Engelhart Darcy C, Granados Jeffry C, Shi Da, Saier Jr Milton H, Baker Michael E, Abagyan Ruben, Nigam Sanjay K

Abstract excerpt

The SLC22 family of OATs, OCTs, and OCTNs is emerging as a central hub of endogenous physiology. Despite often being referred to as "drug" transporters, they facilitate the movement of metabolites and key signaling molecules. An in-depth reanalysis supports a reassignment of these proteins into eight functional subgroups, with four new subgroups arising from the previously defined OAT subclade: OATS1 (SLC22A6,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32150922
DOI: 10.3390/ijms21051791
PMCID: PMC7084758

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