Article

Dual function of DOT1L suppresses tumor intrinsic immunogenicity in hepatocellular carcinoma

2025-05-02

Abstract excerpt

Immune checkpoint inhibitor (ICB) therapy for many cancers remains limited in patients’ overall response rate. Discovery and development of more effective combinatorial approaches is urgent. Here, through CRISPR/Cas9 genetic screens, we identify DOT1L as a versatile epigenetic factor that functions to suppress tumor-intrinsic immunity through a dual mechanism. Depletion of DOT1L induces the expression of transposa...

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Literature Corpus work: 0ce38c27-5d37-583d-bd71-68b5749b7749
DOI: 10.1101/2025.05.01.651793

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