Article

Evaluation of Expanded 2-Aminobenzothiazole Library for Inhibition of <i>Pseudomonas aeruginosa</i> Virulence Phenotypes

2023-05-02

Abstract excerpt

Bacterial resistance to antibiotics is a rapidly increasing threat to human health. New strategies to combat resistant organisms are desperately needed. One potential avenue is targeting two-component systems, which are the main bacterial signal transduction pathways used to regulate development, metabolism, virulence, and antibiotic resistance. These systems consist of a homodimeric membrane-bound sensor histidin...

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Literature Corpus work: ad6d4907-37f2-5ac1-ab09-b589bdb30bb6
DOI: 10.1101/2023.05.02.539119

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