Article

Analysis of MRI-derived spleen iron in the UK Biobank identifies genetic variation linked to iron homeostasis and erythrocyte morphology

2021-11-17

Abstract excerpt

The spleen plays a key role in iron homeostasis. It is the largest filter of the blood and performs iron reuptake from old or damaged erythrocytes. Despite this role, spleen iron concentration has not been measured in a large, population-based cohort. In this study, we quantify spleen iron in 41,764 participants of the UK Biobank using magnetic resonance imaging, and provide the first reference range for spleen ir...

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Literature Corpus work: ad66e3cc-633f-5f0c-bedc-3784ac9c0caa
DOI: 10.1101/2021.11.16.21266431

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