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Article

Analysis of MRI-derived spleen iron in the UK Biobank identifies genetic variation linked to iron homeostasis and hemolysis.

American journal of human genetics - 2 Jun 2022

Sorokin Elena P, Basty Nicolas, Whitcher Brandon, Liu Yi, Bell Jimmy D, Cohen Robert L, Cule Madeleine, Thomas E Louise

Abstract excerpt

The spleen plays a key role in iron homeostasis. It is the largest filter of the blood and performs iron reuptake from old or damaged erythrocytes. Despite this role, spleen iron concentration has not been measured in a large, population-based cohort. In this study, we quantify spleen iron in 41,764 participants of the UK Biobank by using magnetic resonance imaging and provide a reference range for spleen iron in...

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Identifiers

PMID: 35568031
DOI: 10.1016/j.ajhg.2022.04.013
PMCID: PMC9247824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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