Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mycosins Are Required for the Stabilization of the ESX-1 and ESX-5 Type VII Secretion Membrane Complexes

20 Oct 2016

Abstract excerpt

ABSTRACT Pathogenic mycobacteria contain up to five type VII secretion (T7S) systems, ESX-1 to ESX-5. One of the conserved T7S components is the serine protease mycosin (MycP). Strikingly, whereas MycP is essential for secretion, the protease activity of MycP 1 in Mycobacterium tuberculosis has been shown to be dispensable for secretion. The essential role of MycP therefore remains unclear. Here we show that MycP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotic Resistance in Bacteria
Share to Bacterial Genetics and Biotechnology
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27795391
DOI: 10.1128/mbio.01471-16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mycosins Are Required for the Stabilization of the ESX-1 and ESX-5 Type VII Secretion Membrane ComplexesPMID 27795391Read ↗

Type VII Secretion: A Highly Versatile Secretion SystemSemantic proximity Read ↗

ESX secretion system: The gatekeepers of mycobacterial survivability and pathogenesisSemantic proximity Read ↗

PPE and PE_PGRS proteins of <i>Mycobacterium marinum</i> are transported via the type VII secretion system ESX‐5Semantic proximity Read ↗

Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria.Semantic proximity Read ↗

Reconstitution of a minimal ESX-5 type VII secretion system suggests a role for PPE proteins in outer membrane transport of proteinsSemantic proximity Read ↗

Conserved and specialized functions of Type VII secretion systems in non-tuberculous mycobacteriaSemantic proximity Read ↗

Structure and Function of the Mycobacterial Type VII Secretion SystemsSemantic proximity Read ↗

ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial ProteinsSemantic proximity Read ↗

Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulatorSemantic proximity Read ↗

Mycobacterial Secretion Systems ESX-1 and ESX-5 Play Distinct Roles in Host Cell Death and Inflammasome ActivationSemantic proximity Read ↗

Polarly Localized EccE1 Is Required for ESX-1 Function and Stabilization of ESX-1 Membrane Proteins in Mycobacterium tuberculosis.Semantic proximity Read ↗

D iscovery of the type VII ESX‐1 secretion needle?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.