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The ATPases of the mycobacterial type VII secretion system: Structural and mechanistic insights into secretion

22 Nov 2019

Abstract excerpt

Tuberculosis (TB) remains the foremost cause of death by infectious disease and is propagated by the pathogen Mycobacterium tuberculosis (Mtb). The virulence associated with Mtb is mediated by proteins secreted into host cells by the type VII secretion system (T7SS), making this system a candidate for future drug and vaccine development. However, while many of the components involved in the T7SS have been...

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PMID: 31765647
DOI: 10.1016/j.pbiomolbio.2019.11.008

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